Glossary of Terms

Limerick Activator (”Activator”)

Proprietary molecules that activate ABC Transporters

Adenosine triphosphate (ATP)

An important mediator of energy in cells in the body

ATP-binding cassette transporter (ABC) Transporter

ABC Transporters reside in the membranes of cells and use energy from the breakdown of ATP to pump specific molecules out of cells

Calcineurin

A biochemical target for selective activation of cells in the immune system and a target of immunosuppressive drugs

Calcineurin inhibitors (CNI)

Drugs that inhibit calcineurin function

Cyclosporin (CSA)

Commonly used immunosuppressant drug in transplantation medicine that inhibits calcineurin function

Ligand

A molecule that binds to a receptor

NODAT

New Onset Diabetes After Transplant

P-glycoprotein pump (P-gP)

A well characterized member of the ABC-transporter family of proteins

Substrate

A molecule that is acted upon by a transporter or an enzyme

Tacrolimus (TAC or FK506)

Commonly used immunosuppressant drug in transplantation medicine that inhibits calcineurin function

Xenobiotic

A chemical that is not normally produced by a cell